Mammalian Atg8-family proteins are upstream regulators of the lysosomalsystem by controlling MTOR and TFEB

Macroautophagy/autophagy delivers cytoplasmic cargo to lysosomes for degradation. In yeast, the single Atg8 protein plays a role in the formation of autophagosomes whereas in mammalian cells there are five to seven paralogs, referred to as mammalian Atg8s (mAtg8s: GABARAP, GABARAPL1, GABARAPL2, LC3A...

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Bibliografische gegevens
Gepubliceerd in:Autophagy
Hoofdauteurs: Kumar, Suresh, Jain, Ashish, Choi, Seong Won, Peixoto Duarte da Silva, Gustavo, Allers, Lee, Mudd, Michal H., Peters, Ryan Scott, Anonsen, Jan Haug, Rusten, Tor-Erik, Lazarou, Michael, Deretic, Vojo
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Taylor & Francis 2020
Onderwerpen:
Autophagic Punctum
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7751677/
https://ncbi.nlm.nih.gov/pubmed/33070669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2020.1837423
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