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Mammalian Atg8-family proteins are upstream regulators of the lysosomalsystem by controlling MTOR and TFEB
Macroautophagy/autophagy delivers cytoplasmic cargo to lysosomes for degradation. In yeast, the single Atg8 protein plays a role in the formation of autophagosomes whereas in mammalian cells there are five to seven paralogs, referred to as mammalian Atg8s (mAtg8s: GABARAP, GABARAPL1, GABARAPL2, LC3A...
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| Veröffentlicht in: | Autophagy |
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| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Taylor & Francis
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7751677/ https://ncbi.nlm.nih.gov/pubmed/33070669 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2020.1837423 |
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