Mammalian Atg8 proteins regulate lysosome and autolysosome biogenesis through SNAREs

Mammalian homologs of yeast Atg8 protein (mAtg8s) are important in autophagy, but their exact mode of action remains ill‐defined. Syntaxin 17 (Stx17), a SNARE with major roles in autophagy, was recently shown to bind mAtg8s. Here, we identified LC3‐interacting regions (LIRs) in several SNAREs that b...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Gu, Yuexi, Princely Abudu, Yakubu, Kumar, Suresh, Bissa, Bhawana, Choi, Seong Won, Jia, Jingyue, Lazarou, Michael, Eskelinen, Eeva‐Liisa, Johansen, Terje, Deretic, Vojo
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6856626/
https://ncbi.nlm.nih.gov/pubmed/31625181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2019101994
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