Selective Delivery of Dicarboxylates to Mitochondria by Conjugation to a Lipophilic Cation via a Cleavable Linker

[Image: see text] Many mitochondrial metabolites and bioactive molecules contain two carboxylic acid moieties that make them unable to cross biological membranes. Hence, there is considerable interest in facilitating the uptake of these molecules into cells and mitochondria to modify or report on th...

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Publicat a:Mol Pharm
Autors principals: Prag, Hiran A., Kula-Alwar, Duvaraka, Pala, Laura, Caldwell, Stuart T., Beach, Timothy E., James, Andrew M., Saeb-Parsy, Kourosh, Krieg, Thomas, Hartley, Richard C., Murphy, Michael P.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2020
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7482397/
https://ncbi.nlm.nih.gov/pubmed/32692564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.0c00533
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