Unstable Mechanisms of Resistance to Inhibitors of Escherichia coli Lipoprotein Signal Peptidase

Clinical development of antibiotics with novel mechanisms of action to kill pathogenic bacteria is challenging, in part, due to the inevitable emergence of resistance. A phenomenon of potential clinical importance that is broadly overlooked in preclinical development is heteroresistance, an often-un...

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Опубликовано в: :mBio
Главные авторы: Pantua, Homer, Skippington, Elizabeth, Braun, Marie-Gabrielle, Noland, Cameron L., Diao, Jingyu, Peng, Yutian, Gloor, Susan L., Yan, Donghong, Kang, Jing, Katakam, Anand Kumar, Reeder, Janina, Castanedo, Georgette M., Garland, Keira, Komuves, Laszlo, Sagolla, Meredith, Austin, Cary D., Murray, Jeremy, Xu, Yiming, Modrusan, Zora, Xu, Min, Hanan, Emily J., Kapadia, Sharookh B.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2020
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7482066/
https://ncbi.nlm.nih.gov/pubmed/32900806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.02018-20
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