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Bruton’s Tyrosine Kinase (BTK) Inhibitor RN486 Overcomes ABCB1-Mediated Multidrug Resistance in Cancer Cells

Overexpression of ATP-binding cassette subfamily B member 1 (ABCB1) remains one of the most vital factors leading to multidrug resistance (MDR). It is important to enhance the effect and bioavailability of chemotherapeutic drugs that are substrates of ABCB1 transporter in ABCB1-overexpression cancer...

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Bibliografske podrobnosti
izdano v:Front Cell Dev Biol
Main Authors: Dong, Xing-Duo, Zhang, Meng, Ma, Xiubin, Wang, Jing-Quan, Lei, Zi-Ning, Teng, Qiu-Xu, Li, Yi-Dong, Lin, Lusheng, Feng, Weiguo, Chen, Zhe-Sheng
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2020
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7481333/
https://ncbi.nlm.nih.gov/pubmed/32984343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2020.00865
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