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Bruton's tyrosine kinase (Btk) inhibitor tirabrutinib suppresses osteoclastic bone resorption
Osteoclasts are responsible for bone erosion in osteoporosis and rheumatoid arthritis (RA). Both Btk and Tec kinases have essential functions in osteoclast differentiation. Tirabrutinib is a highly potent and dual oral Btk/Tec inhibitor with an IC(50) in the nmol/L range and significantly inhibits t...
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| 出版年: | Bone Rep |
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| 主要な著者: | , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Elsevier
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6431727/ https://ncbi.nlm.nih.gov/pubmed/30956999 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bonr.2019.100201 |
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