Bruton’s Tyrosine Kinase (BTK) Inhibitor RN486 Overcomes ABCB1-Mediated Multidrug Resistance in Cancer Cells

Overexpression of ATP-binding cassette subfamily B member 1 (ABCB1) remains one of the most vital factors leading to multidrug resistance (MDR). It is important to enhance the effect and bioavailability of chemotherapeutic drugs that are substrates of ABCB1 transporter in ABCB1-overexpression cancer...

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Main Authors: Xing-Duo Dong, Meng Zhang, Xiubin Ma, Jing-Quan Wang, Zi-Ning Lei, Qiu-Xu Teng, Yi-Dong Li, Lusheng Lin, Weiguo Feng, Zhe-Sheng Chen
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020-08-01
Colecção:Frontiers in Cell and Developmental Biology
Assuntos:
RN486
Bruton’s tyrosine kinase inhibitor
multidrug resistance
ATP-binding cassette transporter
ABCB1
Acesso em linha:https://www.frontiersin.org/article/10.3389/fcell.2020.00865/full
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