Mutation of the second sialic acid-binding site of influenza A virus neuraminidase drives compensatory mutations in hemagglutinin

Influenza A viruses (IAVs) cause seasonal epidemics and occasional pandemics. Most pandemics occurred upon adaptation of avian IAVs to humans. This adaptation includes a hallmark receptor-binding specificity switch of hemagglutinin (HA) from avian-type α2,3- to human-type α2,6-linked sialic acids. C...

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Publicat a:PLoS Pathog
Autors principals: Du, Wenjuan, Wolfert, Margreet A., Peeters, Ben, van Kuppeveld, Frank J. M., Boons, Geert-Jan, de Vries, Erik, de Haan, Cornelis A. M.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2020
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7480853/
https://ncbi.nlm.nih.gov/pubmed/32853241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008816
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