Integrin VLA-4 as a PET imaging biomarker of hyper-adhesion in transgenic sickle mice

In sickle cell disease (SCD), very late antigen-4 (VLA-4 or integrin α(4)β(1)) mediates the adhesion of reticulocytes to inflamed, proinflammatory endothelium, a key process in promoting vaso-occlusive episodes (VOEs). We hypothesized that a radionuclide tracer targeting VLA-4 could be harnessed as...

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Bibliographic Details
Published in:Blood Adv
Main Authors: Perkins, Lydia A., Nyiranshuti, Lea, Little-Ihrig, Lynda, Latoche, Joseph D., Day, Kathryn E., Zhu, Qin, Tavakoli, Sina, Sundd, Prithu, Novelli, Enrico M., Anderson, Carolyn J.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2020
Subjects:
Vascular Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7479956/
https://ncbi.nlm.nih.gov/pubmed/32882004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020002642
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