AMG 701 induces cytotoxicity of multiple myeloma cells and depletes plasma cells in cynomolgus monkeys

Multiple myeloma (MM) is a hematologic malignancy that is characterized by the accumulation of abnormal plasma cells (PCs) in the bone marrow (BM). Patient outcome may be improved with BiTE (bispecific T-cell engager) molecules, which redirect T cells to lyse tumor cells. B-cell maturation antigen (...

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Veröffentlicht in:Blood Adv
Hauptverfasser: Goldstein, Rebecca L., Goyos, Ana, Li, Chi-Ming, Deegen, Petra, Bogner, Pamela, Sternjak, Alexander, Thomas, Oliver, Klinger, Matthias, Wahl, Joachim, Friedrich, Matthias, Rattel, Benno, Lamas, Edwin, Min, Xiaoshan, Sudom, Athena, Farshbaf, Mozhgan, Coxon, Angela, Balazs, Mercedesz, Arvedson, Tara
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2020
Schlagworte:
Immunobiology and Immunotherapy
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7479952/
https://ncbi.nlm.nih.gov/pubmed/32886754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020002565
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