The immunomodulatory drugs lenalidomide and pomalidomide enhance the potency of AMG 701 in multiple myeloma preclinical models

We investigated here the novel immunomodulation and anti–multiple myeloma (MM) function of T cells engaged by the bispecific T-cell engager molecule AMG 701, and further examined the impact of AMG 701 in combination with immunomodulatory drugs (IMiDs; lenalidomide and pomalidomide). AMG 701 potently...

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Publicado no:Blood Adv
Main Authors: Cho, Shih-Feng, Lin, Liang, Xing, Lijie, Li, Yuyin, Wen, Kenneth, Yu, Tengteng, Hsieh, Phillip A., Munshi, Nikhil, Wahl, Joachim, Matthes, Katja, Friedrich, Matthias, Arvedson, Tara, Anderson, Kenneth C., Tai, Yu-Tzu
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2020
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7479960/
https://ncbi.nlm.nih.gov/pubmed/32898244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020002524
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