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ER-mitochondria contacts promote mtDNA nucleoids active transportation via mitochondrial dynamic tubulation

A human cell contains hundreds to thousands of mitochondrial DNA (mtDNA) packaged into nucleoids. Currently, the segregation and allocation of nucleoids are thought to be passively determined by mitochondrial fusion and division. Here we provide evidence, using live-cell super-resolution imaging, th...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Qin, Jinshan, Guo, Yuting, Xue, Boxin, Shi, Peng, Chen, Yang, Su, Qian Peter, Hao, Huiwen, Zhao, Shujuan, Wu, Congying, Yu, Li, Li, Dong, Sun, Yujie
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7478960/
https://ncbi.nlm.nih.gov/pubmed/32901010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-18202-4
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