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ER-mitochondria contacts couple mtDNA synthesis with mitochondrial division in human cells
Mitochondrial DNA (mtDNA) encodes RNAs and proteins critical for cell function. In human cells, 100–1000s mtDNA copies are replicated asynchronously, packaged into protein-DNA nucleoids, and distributed within a dynamic mitochondrial network. The mechanisms that govern how nucleoids are chosen for r...
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| Udgivet i: | Science |
|---|---|
| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5554545/ https://ncbi.nlm.nih.gov/pubmed/27418514 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaf5549 |
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