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Poor quality Vβ recombination signal sequences stochastically enforce TCRβ allelic exclusion
The monoallelic expression of antigen receptor (AgR) genes, called allelic exclusion, is fundamental for highly specific immune responses to pathogens. This cardinal feature of adaptive immunity is achieved by the assembly of a functional AgR gene on one allele, with subsequent feedback inhibition o...
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| Publicado no: | J Exp Med |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Rockefeller University Press
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7478721/ https://ncbi.nlm.nih.gov/pubmed/32526772 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20200412 |
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