Cell-based artificial APC resistant to lentiviral transduction for efficient generation of CAR-T cells from various cell sources

BACKGROUND: Adoptive cell therapy with chimeric antigen receptor T cells (CAR-T) has become a standard treatment for patients with certain aggressive B cell malignancies and holds promise to improve the care of patients suffering from numerous other cancers in the future. However, the high manufactu...

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Bibliographic Details
Published in:J Immunother Cancer
Main Authors: Schmidts, Andrea, Marsh, Leah C, Srivastava, Ambike A, Bouffard, Amanda A, Boroughs, Angela C, Scarfò, Irene, Larson, Rebecca C, Bedoya, Felipe, Choi, Bryan D, Frigault, Matthew J, Bailey, Stefanie R, Leick, Mark B, Vatsa, Sonika, Kann, Michael C, Prew, Michelle S, Kleinstiver, Benjamin P, Joung, J Keith, Maus, Marcela V
Format: Artigo
Language:Inglês
Published: BMJ Publishing Group 2020
Subjects:
Immune Cell Therapies and Immune Cell Engineering
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7477986/
https://ncbi.nlm.nih.gov/pubmed/32900862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-000990
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