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Acetylation of Aβ(40) Alters Aggregation in the Presence and Absence of Lipid Membranes

A hallmark of Alzheimer’s disease (AD) is the formation of senile plaques comprised of the β-amyloid (Aβ) peptide. Aβ fibrillization is a complex nucleation-dependent process involving a variety of metastable intermediate aggregates and features the formation of inter- and intramolecular salt bridge...

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Pubblicato in:ACS Chem Neurosci
Autori principali: Pilkington, Albert W., Schupp, Jane, Nyman, Morgan, Valentine, Stephen J., Smith, David M., Legleiter, Justin
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7477891/
https://ncbi.nlm.nih.gov/pubmed/31834770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.9b00483
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