Regioselective functionalization of aryl azoles as powerful tool for the synthesis of pharmaceutically relevant targets

Aryl azole scaffolds are present in a wide range of pharmaceutically relevant molecules. Their ortho-selective metalation at the aryl ring is challenging, due to the competitive metalation of the more acidic heterocycle. Seeking a practical access to a key Active Pharmaceutical Ingredient (API) inte...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Lutter, Ferdinand H., Grokenberger, Lucie, Perego, Luca Alessandro, Broggini, Diego, Lemaire, Sébastien, Wagschal, Simon, Knochel, Paul
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7477575/
https://ncbi.nlm.nih.gov/pubmed/32895371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-18188-z
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