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N-Aryl Lactams by Regioselective Ozonation of N-Aryl Cyclic Amines
Ozonation of N-aryl-cyclic amines in organic solvents gave N-aryl-lactams regioselectively. In particular, 4-(4-aminophenyl)-morpolin-3-one, a key intermediate in the preparation of factor Xa inhibitors, was obtained in fair yields. The method represents an alternative approach for the lactamization...
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| Hoofdauteurs: | , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
International Scholarly Research Network
2012
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3767345/ https://ncbi.nlm.nih.gov/pubmed/24052840 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5402/2012/281642 |
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