N-Aryl Lactams by Regioselective Ozonation of N-Aryl Cyclic Amines

Ozonation of N-aryl-cyclic amines in organic solvents gave N-aryl-lactams regioselectively. In particular, 4-(4-aminophenyl)-morpolin-3-one, a key intermediate in the preparation of factor Xa inhibitors, was obtained in fair yields. The method represents an alternative approach for the lactamization...

Full description

Saved in:
Bibliographic Details
Main Authors: Saliu, Francesco, Orlandi, Marco, Bruschi, Maurizio
Format: Artigo
Language:Inglês
Published: International Scholarly Research Network 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3767345/
https://ncbi.nlm.nih.gov/pubmed/24052840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5402/2012/281642
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items