Structural Characterization of N-Protonated Amides. Regioselective N-Activation of Medium-Bridged Twisted Lactams

[Image: see text] The straightforward protonation of lactams by treatment with acid and the full structural characterization of three resulting N-protonated lactams are disclosed. This work provides experimental evidence that N-protonation of amide bonds results in a dramatic increase of non-planari...

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Bibliographic Details
Main Authors: Szostak, Michal, Yao, Lei, Day, Victor W., Powell, Douglas R., Aubé, Jeffrey
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2920036/
https://ncbi.nlm.nih.gov/pubmed/20536127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja101690u
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