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Stability of Medium-Bridged Twisted Amides in Aqueous Solutions

“Twisted” amides containing non-standard dihedral angles are typically hypersensitive to hydrolysis, a feature that has stringently limited their utility in water. We have synthesized a series of bridged lactams that contain a twisted amide linkage but which exhibit enhanced stability in aqueous env...

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Détails bibliographiques
Auteurs principaux: Szostak, Michal, Yao, Lei, Aubé, Jeffrey
Format: Artigo
Langue:Inglês
Publié: 2009
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3281991/
https://ncbi.nlm.nih.gov/pubmed/19178141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo802192v
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