Polygenic risk score for the prediction of breast cancer is related to lesser terminal duct lobular unit involution of the breast

Terminal duct lobular units (TDLUs) are the predominant anatomical structures where breast cancers originate. Having lesser degrees of age-related TDLU involution, measured as higher TDLUs counts or more epithelial TDLU substructures (acini), is related to increased breast cancer risk among women wi...

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Publié dans:NPJ Breast Cancer
Auteurs principaux: Bodelon, Clara, Oh, Hannah, Derkach, Andriy, Sampson, Joshua N., Sprague, Brian L., Vacek, Pamela, Weaver, Donald L., Fan, Shaoqi, Palakal, Maya, Papathomas, Daphne, Xiang, Jackie, Patel, Deesha A., Linville, Laura, Clare, Susan E., Visscher, Daniel W., Mies, Carolyn, Hewitt, Stephen M., Brinton, Louise A., Storniolo, Anna Maria V., He, Chunyan, Chanock, Stephen J., Garcia-Closas, Montserrat, Gierach, Gretchen L., Figueroa, Jonine D.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7477555/
https://ncbi.nlm.nih.gov/pubmed/32964115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41523-020-00184-7
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