Polygenic risk score for the prediction of breast cancer is related to lesser terminal duct lobular unit involution of the breast

Terminal duct lobular units (TDLUs) are the predominant anatomical structures where breast cancers originate. Having lesser degrees of age-related TDLU involution, measured as higher TDLUs counts or more epithelial TDLU substructures (acini), is related to increased breast cancer risk among women wi...

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Udgivet i:NPJ Breast Cancer
Main Authors: Bodelon, Clara, Oh, Hannah, Derkach, Andriy, Sampson, Joshua N., Sprague, Brian L., Vacek, Pamela, Weaver, Donald L., Fan, Shaoqi, Palakal, Maya, Papathomas, Daphne, Xiang, Jackie, Patel, Deesha A., Linville, Laura, Clare, Susan E., Visscher, Daniel W., Mies, Carolyn, Hewitt, Stephen M., Brinton, Louise A., Storniolo, Anna Maria V., He, Chunyan, Chanock, Stephen J., Garcia-Closas, Montserrat, Gierach, Gretchen L., Figueroa, Jonine D.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7477555/
https://ncbi.nlm.nih.gov/pubmed/32964115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41523-020-00184-7
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