Altering MYC phosphorylation in the epidermis increases the stem cell population and contributes to the development, progression, and metastasis of squamous cell carcinoma

cMYC (MYC) is a potent oncoprotein that is subject to post-translational modifications that affect its stability and activity. Here, we show that Serine 62 phosphorylation, which increases MYC stability and oncogenic activity, is elevated while Threonine 58 phosphorylation, which targets MYC for deg...

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發表在:Oncogenesis
Main Authors: Wang, Xiaoyan, Langer, Ellen M., Daniel, Colin J., Janghorban, Mahnaz, Wu, Vivian, Wang, Xiao-Jing, Sears, Rosalie C.
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2020
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7477541/
https://ncbi.nlm.nih.gov/pubmed/32895364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41389-020-00261-3
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