The tumor suppressor phosphatase PP2A-B56α regulates stemness and promotes the initiation of malignancies in a novel murine model

Protein phosphatase 2A (PP2A) is a ubiquitously expressed Serine-Threonine phosphatase mediating 30–50% of protein phosphatase activity. PP2A functions as a heterotrimeric complex, with the B subunits directing target specificity to regulate the activity of many key pathways that control cellular ph...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Janghorban, Mahnaz, Langer, Ellen M., Wang, Xiaoyan, Zachman, Derek, Daniel, Colin J., Hooper, Jody, Fleming, William H., Agarwal, Anupriya, Sears, Rosalie C.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5708644/
https://ncbi.nlm.nih.gov/pubmed/29190822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0188910
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