Inactivation of the Dlc1 gene cooperates with down-regulation of p15(INK4b) and p16(Ink4a) leading to neoplastic transformation and poor prognosis in human cancer

The tumor suppressor gene deleted in liver cancer-1 (DLC1), which encodes a protein with strong RhoGAP (GTPase activating protein) activity and weak Cdc42GAP activity, is inactivated in various human malignancies. Following Dlc1 inactivation, mouse embryo fibroblasts (MEFs) with a conditional Dlc1 k...

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發表在:Cancer Res
Main Authors: Qian, Xiaolan, Durkin, Marian E., Wang, Dunrui, Tripathi, Brajendra K., Olson, Lyra, Yang, Xu-yu, Vass, William C., Popescu, Nicholas C., Lowy, Douglas R.
格式: Artigo
語言:Inglês
出版: 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7477393/
https://ncbi.nlm.nih.gov/pubmed/23010077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-2368
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