Wird geladen...
Inactivation of the Dlc1 gene cooperates with down-regulation of p15(INK4b) and p16(Ink4a) leading to neoplastic transformation and poor prognosis in human cancer
The tumor suppressor gene deleted in liver cancer-1 (DLC1), which encodes a protein with strong RhoGAP (GTPase activating protein) activity and weak Cdc42GAP activity, is inactivated in various human malignancies. Following Dlc1 inactivation, mouse embryo fibroblasts (MEFs) with a conditional Dlc1 k...
Gespeichert in:
| Veröffentlicht in: | Cancer Res |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2012
|
| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7477393/ https://ncbi.nlm.nih.gov/pubmed/23010077 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-2368 |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|