Ubiquitin ligase SMURF2 enhances epidermal growth factor receptor stability and tyrosine-kinase inhibitor resistance

The discovery of activating epidermal growth factor receptor (EGFR) mutations spurred the use of EGFR tyrosine kinase inhibitors (TKIs), such as erlotinib, as the first-line treatment of lung cancers. We previously reported that differential degradation of TKI-sensitive (e.g. L858R) and resistant (T...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Ray, Paramita, Raghunathan, Krishnan, Ahsan, Aarif, Allam, Uday Sankar, Shukla, Shirish, Basrur, Venkatesha, Veatch, Sarah, Lawrence, Theodore S., Nyati, Mukesh K., Ray, Dipankar
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2020
Assuntos:
Protein Synthesis and Degradation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7476725/
https://ncbi.nlm.nih.gov/pubmed/32669362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.013519
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