KRAS Protein Stability Is Regulated through SMURF2: UBCH5 Complex-Mediated β-TrCP1 Degradation

Attempts to target mutant KRAS have been unsuccessful. Here, we report the identification of Smad ubiquitination regulatory factor 2 (SMURF2) and UBCH5 as a critical E3:E2 complex maintaining KRAS protein stability. Loss of SMURF2 either by small interfering RNA/short hairpin RNA (siRNA/shRNA) or by...

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Main Authors: Shukla, Shirish, SankarAllam, Uday, Ahsan, Aarif, Chen, Guoan, Krishnamurthy, Pranathi Meda, Marsh, Katherine, Rumschlag, Matthew, Shankar, Sunita, Whitehead, Christopher, Schipper, Matthew, Basrur, Venkatesha, Southworth, Daniel R, Chinnaiyan, Arul M, Rehemtulla, Alnawaz, Beer, David G, Lawrence, Theodore S, Nyati, Mukesh K, Ray, Dipankar
Formato: Artigo
Idioma:Inglês
Publicado: Neoplasia Press Inc. 2014
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3978392/
https://ncbi.nlm.nih.gov/pubmed/24709419
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