A novel reporter for real-time, quantitative imaging of AKT-directed K63-poly-ubiquitination in living cells

Post-translational K63-linked poly-ubiquitination of AKT is required for its membrane recruitment and phosphorylation dependent activation in response to growth-factor stimulation. Current assays for target specific poly-ubiquitination involve cumbersome enzymatic preparations and semi-quantitative...

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Sparad:
Bibliografiska uppgifter
I publikationen:Oncotarget
Huvudupphovsmän: Nyati, Shyam, Chaudhry, Nauman, Chatur, Areeb, Gregg, Brandon S., Kimmel, Lauren, Khare, Dheeraj, Basrur, Venkatesha, Ray, Dipankar, Rehemtulla, Alnawaz
Materialtyp: Artigo
Språk:Inglês
Publicerad: Impact Journals LLC 2018
Ämnen:
Research Paper
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5834254/
https://ncbi.nlm.nih.gov/pubmed/29541398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.24323
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