Hotspots of Aberrant Enhancer Activity in Fibrolamellar Carcinoma Reveal Candidate Oncogenic Pathways and Therapeutic Vulnerabilities

Fibrolamellar carcinoma (FLC) is a rare, therapeutically intractable liver cancer that disproportionately affects youth. Although FLC tumors exhibit a distinct gene expression profile, the chromatin regulatory landscape and the genes most critical for tumor cell survival remain unclear. Here, we use...

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Udgivet i:Cell Rep
Main Authors: Dinh, Timothy A., Sritharan, Ramja, Smith, F. Donelson, Francisco, Adam B., Ma, Rosanna K., Bunaciu, Rodica P., Kanke, Matt, Danko, Charles G., Massa, Andrew P., Scott, John D., Sethupathy, Praveen
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7474926/
https://ncbi.nlm.nih.gov/pubmed/32294439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.03.073
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