Hotspots of Aberrant Enhancer Activity in Fibrolamellar Carcinoma Reveal Candidate Oncogenic Pathways and Therapeutic Vulnerabilities

Fibrolamellar carcinoma (FLC) is a rare, therapeutically intractable liver cancer that disproportionately affects youth. Although FLC tumors exhibit a distinct gene expression profile, the chromatin regulatory landscape and the genes most critical for tumor cell survival remain unclear. Here, we use...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Cell Rep
Autores principales: Dinh, Timothy A., Sritharan, Ramja, Smith, F. Donelson, Francisco, Adam B., Ma, Rosanna K., Bunaciu, Rodica P., Kanke, Matt, Danko, Charles G., Massa, Andrew P., Scott, John D., Sethupathy, Praveen
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7474926/
https://ncbi.nlm.nih.gov/pubmed/32294439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.03.073
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares