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Model of fibrolamellar hepatocellular carcinomas reveals striking enrichment in cancer stem cells

The aetiology of human fibrolamellar hepatocellular carcinomas (hFL-HCCs), cancers occurring increasingly in children to young adults, is poorly understood. We present a transplantable tumour line, maintained in immune-compromised mice, and validate it as a bona fide model of hFL-HCCs by multiple me...

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Bibliografiske detaljer
Udgivet i:Nat Commun
Main Authors: Oikawa, Tsunekazu, Wauthier, Eliane, Dinh, Timothy A., Selitsky, Sara R., Reyna-Neyra, Andrea, Carpino, Guido, Levine, Ronald, Cardinale, Vincenzo, Klimstra, David, Gaudio, Eugenio, Alvaro, Domenico, Carrasco, Nancy, Sethupathy, Praveen, Reid, Lola M.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Pub. Group 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4600730/
https://ncbi.nlm.nih.gov/pubmed/26437858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9070
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