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The αβTCR mechanosensor exploits dynamic ectodomain allostery to optimize its ligand recognition site
Each [Formula: see text] T cell receptor (TCR) functions as a mechanosensor. The TCR is comprised of a clonotypic TCR [Formula: see text] ligand-binding heterodimer and the noncovalently associated CD3 signaling subunits. When bound by ligand, an antigenic peptide arrayed by a major histocompatibili...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7474670/ https://ncbi.nlm.nih.gov/pubmed/32796106 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2005899117 |
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