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The αβ T Cell Receptor Is an Anisotropic Mechanosensor

Thymus-derived lymphocytes protect mammalian hosts against virus- or cancer-related cellular alterations through immune surveillance, eliminating diseased cells. In this process, T cell receptors (TCRs) mediate both recognition and T cell activation via their dimeric αβ, CD3ϵγ, CD3ϵδ, and CD3ζζ subu...

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Autori principali: Kim, Sun Taek, Takeuchi, Koh, Sun, Zhen-Yu J., Touma, Maki, Castro, Carlos E., Fahmy, Amr, Lang, Matthew J., Wagner, Gerhard, Reinherz, Ellis L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2781503/
https://ncbi.nlm.nih.gov/pubmed/19755427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.052712
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