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Talin folding as the tuning fork of cellular mechanotransduction

Cells continually sample their mechanical environment using exquisite force sensors such as talin, whose folding status triggers mechanotransduction pathways by recruiting binding partners. Mechanical signals in biology change quickly over time and are often embedded in noise; however, the mechanics...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Tapia-Rojo, Rafael, Alonso-Caballero, Álvaro, Fernández, Julio M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2020
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7474635/
https://ncbi.nlm.nih.gov/pubmed/32817549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2004091117
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