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Talin folding as the tuning fork of cellular mechanotransduction

Cells continually sample their mechanical environment using exquisite force sensors such as talin, whose folding status triggers mechanotransduction pathways by recruiting binding partners. Mechanical signals in biology change quickly over time and are often embedded in noise; however, the mechanics...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Tapia-Rojo, Rafael, Alonso-Caballero, Álvaro, Fernández, Julio M.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7474635/
https://ncbi.nlm.nih.gov/pubmed/32817549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2004091117
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