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KAT5 acetylates cGAS to promote innate immune response to DNA virus
The DNA sensor cGMP-AMP synthase (cGAS) senses cytosolic microbial or self DNA to initiate a MITA/STING-dependent innate immune response. cGAS is regulated by various posttranslational modifications at its C-terminal catalytic domain. Whether and how its N-terminal unstructured domain is regulated b...
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| I publikationen: | Proc Natl Acad Sci U S A |
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| Huvudupphovsmän: | , , , , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
National Academy of Sciences
2020
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7474609/ https://ncbi.nlm.nih.gov/pubmed/32817552 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1922330117 |
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