Quantifying Glioblastoma Drug Response Dynamics Incorporating Treatment Sensitivity and Blood Brain Barrier Penetrance From Experimental Data

Many drugs investigated for the treatment of glioblastoma (GBM) have had disappointing clinical trial results. Efficacy of these agents is dependent on adequate delivery to sensitive tumor cell populations, which is limited by the blood-brain barrier (BBB). Additionally, tumor heterogeneity can lead...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Front Physiol
Κύριοι συγγραφείς: Massey, Susan Christine, Urcuyo, Javier C., Marin, Bianca Maria, Sarkaria, Jann N., Swanson, Kristin R.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Frontiers Media S.A. 2020
Θέματα:
Physiology
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7472531/
https://ncbi.nlm.nih.gov/pubmed/32973540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2020.00830
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