Ubiquilin-2 differentially regulates polyglutamine disease proteins

Divergent protein context helps explain why polyglutamine expansion diseases differ clinically and pathologically. This heterogeneity may also extend to how polyglutamine disease proteins are handled by cellular pathways of proteostasis. Studies suggest, for example, that the ubiquitin-proteasome sh...

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Detalhes bibliográficos
Publicado no:Hum Mol Genet
Main Authors: Gerson, Julia E, Safren, Nathaniel, Fischer, Svetlana, Patel, Ronak, Crowley, Emily V, Welday, Jacqueline P, Windle, Alexandra K, Barmada, Sami, Paulson, Henry L, Sharkey, Lisa M
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
1 General Article - US Office
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7471500/
https://ncbi.nlm.nih.gov/pubmed/32681165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddaa152
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