The oncofetal RNA-binding protein IGF2BP1 is a druggable, post-transcriptional super-enhancer of E2F-driven gene expression in cancer

The IGF2 mRNA-binding protein 1 (IGF2BP1) is a non-catalytic post-transcriptional enhancer of tumor growth upregulated and associated with adverse prognosis in solid cancers. However, conserved effector pathway(s) and the feasibility of targeting IGF2BP1 in cancer remained elusive. We reveal that IG...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Müller, Simon, Bley, Nadine, Busch, Bianca, Glaß, Markus, Lederer, Marcell, Misiak, Claudia, Fuchs, Tommy, Wedler, Alice, Haase, Jacob, Bertoldo, Jean Borges, Michl, Patrick, Hüttelmaier, Stefan
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
Molecular Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7470957/
https://ncbi.nlm.nih.gov/pubmed/32761127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa653
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