The oncofetal RNA-binding protein IGF2BP1 is a druggable, post-transcriptional super-enhancer of E2F-driven gene expression in cancer

The IGF2 mRNA-binding protein 1 (IGF2BP1) is a non-catalytic post-transcriptional enhancer of tumor growth upregulated and associated with adverse prognosis in solid cancers. However, conserved effector pathway(s) and the feasibility of targeting IGF2BP1 in cancer remained elusive. We reveal that IG...

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Dades bibliogràfiques
Publicat a:Nucleic Acids Res
Autors principals: Müller, Simon, Bley, Nadine, Busch, Bianca, Glaß, Markus, Lederer, Marcell, Misiak, Claudia, Fuchs, Tommy, Wedler, Alice, Haase, Jacob, Bertoldo, Jean Borges, Michl, Patrick, Hüttelmaier, Stefan
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2020
Matèries:
Molecular Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7470957/
https://ncbi.nlm.nih.gov/pubmed/32761127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa653
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