IGF2BP1 enhances an aggressive tumor cell phenotype by impairing miRNA-directed downregulation of oncogenic factors

The oncofetal IGF2 mRNA binding proteins (IGF2BPs) are upregulated in most cancers but their paralogue-specific roles in tumor cells remain poorly understood. In a panel of five cancer-derived cell lines, IGF2BP1 shows highly conserved oncogenic potential. Consistently, the deletion of IGF2BP1 impai...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Müller, Simon, Bley, Nadine, Glaß, Markus, Busch, Bianca, Rousseau, Vanessa, Misiak, Danny, Fuchs, Tommy, Lederer, Marcell, Hüttelmaier, Stefan
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
RNA and RNA-protein complexes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6158595/
https://ncbi.nlm.nih.gov/pubmed/29660014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky229
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