DNA backbone interactions impact the sequence specificity of DNA sulfur-binding domains: revelations from structural analyses

The sulfur atom of phosphorothioated DNA (PT-DNA) is coordinated by a surface cavity in the conserved sulfur-binding domain (SBD) of type IV restriction enzymes. However, some SBDs cannot recognize the sulfur atom in some sequence contexts. To illustrate the structural determinants for sequence spec...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Yu, Hao, Li, Jiayi, Liu, Guang, Zhao, Gong, Wang, Yuli, Hu, Wenyue, Deng, Zixin, Wu, Geng, Gan, Jianhua, Zhao, Yi-Lei, He, Xinyi
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
Structural Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7470945/
https://ncbi.nlm.nih.gov/pubmed/32621606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa574
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