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Chemical and structural investigation of the paroxetine-human serotonin transporter complex
Antidepressants target the serotonin transporter (SERT) by inhibiting serotonin reuptake. Structural and biochemical studies aiming to understand binding of small-molecules to conformationally dynamic transporters like SERT often require thermostabilizing mutations and antibodies to stabilize a spec...
Tallennettuna:
| Julkaisussa: | eLife |
|---|---|
| Päätekijät: | , , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
eLife Sciences Publications, Ltd
2020
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7470834/ https://ncbi.nlm.nih.gov/pubmed/32618269 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.56427 |
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