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Thermostabilization of the Human Serotonin Transporter in an Antidepressant-Bound Conformation

Serotonin is a ubiquitous chemical transmitter with particularly important roles in the gastrointestinal, cardiovascular and central nervous systems. Modulation of serotonergic signaling occurs, in part, by uptake of the transmitter by the serotonin transporter (SERT). In the brain, SERT is the targ...

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Bibliografiske detaljer
Udgivet i:PLoS One
Main Authors: Green, Evan M., Coleman, Jonathan A., Gouaux, Eric
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4687910/
https://ncbi.nlm.nih.gov/pubmed/26695939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0145688
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