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Thermostabilization and purification of the human dopamine transporter (hDAT) in an inhibitor and allosteric ligand bound conformation

The human dopamine transporter (hDAT) plays a major role in dopamine homeostasis and regulation of neurotransmission by clearing dopamine from the extracellular space using secondary active transport. Dopamine is an essential monoamine chemical messenger that regulates reward seeking behavior, motor...

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Bibliografiske detaljer
Udgivet i:PLoS One
Main Authors: Navratna, Vikas, Tosh, Dilip K., Jacobson, Kenneth A., Gouaux, Eric
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6028122/
https://ncbi.nlm.nih.gov/pubmed/29965988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0200085
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