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Serotonin transporter-ibogaine complexes illuminate mechanisms of inhibition and transport

The serotonin transporter (SERT) regulates neurotransmitter homeostasis through the sodium-and chloride-dependent recycling of serotonin into presynaptic neurons(1–3). Major depression and anxiety disorders are treated using selective serotonin reuptake inhibitors (SSRIs), small molecules that compe...

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Detalhes bibliográficos
Publicado no:Nature
Main Authors: Coleman, Jonathan A., Yang, Dongxue, Zhao, Zhiyu, Wen, Po-Chao, Yoshioka, Craig, Tajkhorshid, Emad, Gouaux, Eric
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6750207/
https://ncbi.nlm.nih.gov/pubmed/31019304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-019-1135-1
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