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Upregulation of TRPM3 in nociceptors innervating inflamed tissue

Genetic ablation or pharmacological inhibition of the heat-activated cation channel TRPM3 alleviates inflammatory heat hyperalgesia, but the underlying mechanisms are unknown. We induced unilateral inflammation of the hind paw in mice, and directly compared expression and function of TRPM3 and two o...

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Detalles Bibliográficos
Publicado en:eLife
Main Authors: Mulier, Marie, Van Ranst, Nele, Corthout, Nikky, Munck, Sebastian, Vanden Berghe, Pieter, Vriens, Joris, Voets, Thomas, Moilanen, Lauri
Formato: Artigo
Idioma:Inglês
Publicado: eLife Sciences Publications, Ltd 2020
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7470828/
https://ncbi.nlm.nih.gov/pubmed/32880575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.61103
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