High-resolution analysis of Merkel Cell Polyomavirus in Merkel Cell Carcinoma reveals distinct integration patterns and suggests NHEJ and MMBIR as underlying mechanisms

Merkel Cell Polyomavirus (MCPyV) is the etiological agent of the majority of Merkel Cell Carcinomas (MCC). MCPyV positive MCCs harbor integrated, defective viral genomes that constitutively express viral oncogenes. Which molecular mechanisms promote viral integration, if distinct integration pattern...

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Udgivet i:PLoS Pathog
Main Authors: Czech-Sioli, Manja, Günther, Thomas, Therre, Marlin, Spohn, Michael, Indenbirken, Daniela, Theiss, Juliane, Riethdorf, Sabine, Qi, Minyue, Alawi, Malik, Wülbeck, Corinna, Fernandez-Cuesta, Irene, Esmek, Franziska, Becker, Jürgen C., Grundhoff, Adam, Fischer, Nicole
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7470373/
https://ncbi.nlm.nih.gov/pubmed/32833988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008562
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