High-Affinity Rb Binding, p53 Inhibition, Subcellular Localization, and Transformation by Wild-Type or Tumor-Derived Shortened Merkel Cell Polyomavirus Large T Antigens

Interference with tumor suppressor pathways by polyomavirus-encoded tumor antigens (T-Ags) can result in transformation. Consequently, it is thought that T-Ags encoded by Merkel cell polyomavirus (MCPyV), a virus integrated in ∼90% of all Merkel cell carcinoma (MCC) cases, are major contributors to...

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Main Authors: Borchert, Sophie, Czech-Sioli, Manja, Neumann, Friederike, Schmidt, Claudia, Wimmer, Peter, Dobner, Thomas, Grundhoff, Adam, Fischer, Nicole
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2014
Teme:
Transformation and Oncogenesis
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3957953/
https://ncbi.nlm.nih.gov/pubmed/24371076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02916-13
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