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Coumarin carbonic anhydrase inhibitors from natural sources

Coumarins constitute a relatively new class of inhibitors of the zinc enzyme carbonic anhydrase (CA, EC 4.2.1.1), possessing a unique inhibition mechanism, acting as “prodrug inhibitors.” They undergo the hydrolysis of the lactone ring mediated by the esterase activity of CA. The formed 2-hydroxy-ci...

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Podrobná bibliografie
Vydáno v:J Enzyme Inhib Med Chem
Hlavní autor: Supuran, Claudiu T.
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7470141/
https://ncbi.nlm.nih.gov/pubmed/32779543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2020.1788009
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